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RTLC2419

RTLC2419 Radioactivity TLC Scanner
Today radiochemical purity control is absolutely essential to ensure the accuracy of the radiopharmaceutical-based medical analysis, so the RTLC2419 from Control Farayand Pasargad (CFP) evaluates the radiochemical purity of specific radiopharmaceuticals used in nuclear medicine procedures. The RTLC2419 is well suited to the busy nuclear medicine department with many procedures to perform.

Video:

Features:

  • Extremely high counting rate
  • One trace scan 25mm x 200mm
  • Fast, automated and reliable scans
  • High sensitivity for all radioisotopes
  • Optional beta probe for PET applications
  • Variable scan speeds from 0.1 - 60 (mm/sec)
  • Very high counting rate and dead time correction
  • Spectroscopic analysis of radiopharmaceutical purity
  • Full detector and data acquisition control via application software
  • Performs thin-layer Chromatography (TLC) using a high-resolution NaI detector
  • Daily quality control of radiopharmaceuticals used in nuclear medicine procedures
  • Durable and versatile
  • Splash resistant design
  • Wide temperature range
  • Ready for field operation
  • Easy system set-up and maintenance
  • Continuous operation under severe environmental condition
  • Robust and suitable for use in challenging conditions
  • Easy to use system with maximum flexibility and automatic positioning system
  • Integrated digital MCA with 4096 channel resolution and automatic decay correction and peak integration
  • Supports all data extraction and reanalysis of stored data

Descriptions:

The standard software provides a graphical user interface for TLC scan, gamma-ray spectroscopy, detector control, data acquisition, quality assurance (QA) and database management. The provided factory programmed protocols may be supplemented by user defined protocols. The protocols provide automatic control of the detector scan, the acquisition as well as graphical display and analysis. QA is assured by the quality control procedure and trending analysis of the QA data as a function of time. The database option supports the extraction and re-analysis of all stored data. Various procedures needed for radio chromatography are implemented in the software of RTLC2419. The chromatography procedure starts with definition of “Drop Point” and “Front End” where the user can define the starting and end of chromatography. User can also define the “Time” for the whole test and the “Repeat” number of test. Together with these information, the user provides various information that will be printed in the final report and will be used to identify the person who perform the test and its exact date and time. After this initialization setting, the chromatography test will be started and in the “Time” parameter defined by the user, the test will end. By finishing the scan, various features for the device will be activated. The user can define a specific energy range and the device will immediately visualize the chromatogram for the corresponding range. On the other hand, the user can also define an interval along the test length and software will immediately generate the spectrum corresponding to that interval. Various smoothing operations for both chromatogram and spectrum are applicable in the software. For chromatographic analysis, the user can easily define “Radiopharmaceutical”, “impurity” and “Background” regions and then software will perform the analysis and show the result in the table placed on the upper right corner of the software. The report generated by the user present a summary result of the test where analysis result table, whole spectrum and chromatogram are displayed. Also the color of final report can also be customized based on the user preferences. Altogether RTLC2419 is a total solution for radio chromatography tests which provide the user with various analysis setting parameters, data visualization procedures and reports.

Input(s)

Power

48V (1.25A) AC  to DC adaptor

LEMO PC interface

DC +5V LEMO 5 pin (200mA) for PC communication

Output(s)

No output signal

Control(s)

knob

This knob provides the user with manual control over the device slider.

Power Push button

Push to turn device ON and hold for 3 seconds to turn device OFF (long press)

While device ON push key to change mode (short press)

LEMO port

Setting configuration via LEMO 5 pin (A), USB (B) cable (set and read all data)

Indicator(s)

No indicator

Performance

Speed

0.1 – 60mm/sec

Travel length

200mm

Strip size

25mm x 200mm

Collimators

Type1: For NaI(Tl) Detector (X and Gamma) 

Type2: For Plastic Detector (Beta) 

Detector

NaI(Tl)

1” x 1”

PVT( optional)

0.25mm

Data Acquisition and Analysis

Processor

FPGA technology with Arm9, 32 bit 200MHz

OS

Built in Windows 7 or higher versions

Software

RTLC2419 (SOFTWARE)

Measurement/Spectrum

High Voltage

0 - 1500V (DAC 12bit) 0.2mA

Energy channel (selective by admin)

From 0 to 1024keV

From 0 to 2048keV

From 0 to 3072keV

From 0 to 4096keV

Energy calibration

Non-linear empirical function or linear Calibration (polynomial fit)

ROI selection

Radiopharmaceuticals (arbitrary number of RoI)

Impurity (arbitrary number of RoI)

Background (one RoI)

ADC

Channels

12bit in 4096CH @120Mhz FRQ

Conversion time

200nsec with 8.3nsec time interval

Digital Signal Processing

12-bit and 120MHz ADC

Charge sensitive preamplifier gain:10 – 150mV/pC (selectable)

Amplifier coarse gain: (x1 to 150x) in 15 step

Amplifier fine gain: (0 - 2x) in 65536 step

Integration time filter for the energy calculation with software adjustable rise time in the range 0 to 0.546ms @80Mhz in 0-65536 step

Trigger threshold software adjustment (0 to 100% scale) in 1024 step

Software fine tuning of the Pole-Zero cancellation

Software gain stabilization

Pile-up rejection and live time correction

Baseline restorer with programmable averaging

Catalog
File Format 01. RTLC2419_catalog.pdf en 12/20/2020 3:16:21 PM
File Format 01. RTLC2419_persian catalog.pdf fa 12/20/2020 3:16:30 PM
  • Nuclear medicine
  • Routine quality control of radiopharmaceuticals containing 68Ga, 177Lu, 90Y, 18F, 99mTc, 123I and other
  • Radiochemical purity measurements
  • Online inspection
  • PET and SPECT quality control
  • Quantitative and qualitative analysis of radioactive compounds
  • Development and completion of the chromatographic process
  • Radio scanning and documentation
  • Pharmaceutical metabolite analysis
  • Radiotracer toxicology studies
  • TLC of radiopharmaceuticals labeled with gamma, high energy beta and positron emitters for R&D

PC software

RTLC2419 (SOFTWARE): The system includes RTLC2419 software for instrument control and data analysis. Quantitation of peaks is automatically performed and a report showing the method used, chromatogram and different radioactive information is generated. This software provides an easy-to-use interface for RTLC2419 operation and radio-chromatographic analysis, including instrument control, method definition and storage, data acquisition, quantitative analysis and reporting functions.

Figure 1: Experimental setup window where the user can set various test parameters

Figure 2: Data acquisition window displayed when radio chromatography is being performed.

Figure 3: Typical software report where the user can customize the color (color, gray or monochromic)

Input /Output (Using RTLC2419 software)

USB

Data Output formats

CSV, TXT, XLS, DOC 

image

Figure 1: Experiment setup window

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Figure 2: Data acquisition window

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     Figure 3: Typical software report

Unit:RTLC2419 

Electrical

Power required

Standard version +48V (1.25A) AC to DC adaptor

Physical

Dimensions (L     H)

450 x 230 x 290 cm (L x W x H)

Weight

16.60kg

Mechanical

image

Storage temperature

0°C to 50°C

Operating temperature

10°C to 45°C

Relative humidity

10 to 80%